Engineering
Chemistry
Integrated Rate Law
Question

A simple mechanism for enzyme-catalyzed reaction is given by the following set of equations

  

 E                  +              S                ⇌                      ES

(enzyme)                   (reactant)                       (intermediate-1)

ES              ⇌                              EP

(intermediate-1)                  (intermediate-2)                        

EP               ⇌                   E            +          P

(intermediate-2)            (enzyme)           (product)

This is known as the Michaelis–Menten mechanism. The potential energy diagram is shown in the fig. Which of the following sets of identifications is correct ? (Assume that the temperature and pressure are constant).

ES Activated complex EP Activated complex
E + S ES EP E + S
E + P EP ES E + S
EP Activated complex ES Activated complex
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Solution
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Intermediate and product have less potential energy than activated complex.

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